Splicing factor derived circular RNA circCAMSAP1 accelerates nasopharyngeal carcinoma tumorigenesis via a SERPINH1/c-Myc positive feedback loop.
Yian WangQijia YanYongzhen MoYuhang LiuYumin WangShanshan ZhangCan GuoFuyan WangGuiyuan LiZhaoyang ZengZhaoyang ZengPublished in: Molecular cancer (2022)
Our findings revealed that circCAMSAP1 promotes NPC proliferation and metastasis by binding to the 3'UTR of SERPINH1, suggesting that the positive feedback of circCAMSAP1-SERPINH1-c-Myc may serve as a prognostic biomarker or therapeutic target in patients with NPC.
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