Synthesis, preclinical, and initial clinical evaluation of integrin α V β 3 and gastrin-releasing peptide receptor (GRPR) dual-targeting radiotracer [ 68 Ga]Ga-RGD-RM26-03.
Xuejun WenRongxi WangPengfei XuMengqi ShiQingyao ShangXueyuan ZengXinying ZengJia LiuXin WangZhaohui ZhuZhide GuoXiaoyuan ChenJingjing ZhangPublished in: European journal of nuclear medicine and molecular imaging (2024)
Ga]Ga-RM26 monomer. The first-in-human study showed high TBRs in patients, suggesting favorable pharmacokinetics and high clinical feasibility for PET/CT imaging of cancer.
Keyphrases
- pet ct
- clinical evaluation
- end stage renal disease
- positron emission tomography
- endothelial cells
- ejection fraction
- newly diagnosed
- chronic kidney disease
- high resolution
- papillary thyroid
- squamous cell carcinoma
- peritoneal dialysis
- prognostic factors
- stem cells
- computed tomography
- cancer therapy
- bone marrow
- induced pluripotent stem cells
- cell therapy
- patient reported outcomes
- mesenchymal stem cells
- mass spectrometry
- lymph node metastasis
- photodynamic therapy
- simultaneous determination
- fluorescence imaging