Structures, Sources, Identification/Quantification Methods, Health Benefits, Bioaccessibility, and Products of Isorhamnetin Glycosides as Phytonutrients.
Hong WangLijia ChenBinrui YangJun DuLiang ChenYi-Ming LiFujiang GuoPublished in: Nutrients (2023)
In recent years, people have tended to consume phytonutrients and nutrients in their daily diets. Isorhamnetin glycosides (IGs) are an essential class of flavonoids derived from dietary and medicinal plants such as Opuntia ficus-indica , Hippophae rhamnoides , and Ginkgo biloba . This review summarizes the structures, sources, quantitative and qualitative analysis technologies, health benefits, bioaccessibility, and marketed products of IGs. Routine and innovative assay methods, such as IR, TLC, NMR, UV, MS, HPLC, UPLC, and HSCCC, have been widely used for the characterization and quantification of IGs. All of the therapeutic effects of IGs discovered to date are collected and discussed in this study, with an emphasis on the relevant mechanisms of their health-promoting effects. IGs exhibit diverse biological activities against cancer, diabetes, hepatic diseases, obesity, and thrombosis. They exert therapeutic effects through multiple networks of underlying molecular signaling pathways. Owing to these benefits, IGs could be utilized to make foods and functional foods. IGs exhibit higher bioaccessibility and plasma concentrations and longer average residence time in blood than aglycones. Overall, IGs as phytonutrients are very promising and have excellent application potential.
Keyphrases
- healthcare
- public health
- high resolution
- mental health
- type diabetes
- mass spectrometry
- weight loss
- metabolic syndrome
- health information
- systematic review
- health risk assessment
- multiple sclerosis
- signaling pathway
- pulmonary embolism
- heavy metals
- health promotion
- squamous cell carcinoma
- simultaneous determination
- human health
- weight gain
- papillary thyroid
- risk assessment
- skeletal muscle
- climate change
- young adults
- epithelial mesenchymal transition
- cell proliferation
- squamous cell
- solid phase extraction