Indolent feature of Helicobacter pylori-uninfected intramucosal signet ring cell carcinomas with CDH1 mutations.

Mitsuhiro Nikaido Nobuyuki Kakiuchi Shin'ichi MiyamotoTomonori HiranoYasuhide TakeuchiTaro FunakoshiAkira YokoyamaTatsuki OgasawaraYoshihiro YamamotoAtsushi YamadaTakeshi SetoyamaTakahiro ShimizuYukari KatoSuguru UoseTakaki SakuraiSachiko MinamiguchiKazutaka ObamaYoshiharu SakaiManabu MutoTsutomu ChibaSeishi OgawaHiroshi Seno

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2021)

Impaired E-cadherin function due to CDH1 mutation was considered as an early carcinogenic event of Hp-uninfected intramucosal SRCC. Genetic and clinical analyses suggest that Hp-uninfected intramucosal SRCCs may be less likely to develop into advanced DGCs.

Keyphrases

helicobacter pylori
hiv infected
helicobacter pylori infection
antiretroviral therapy
single cell
genome wide
cell therapy
high grade
gene expression
dna methylation
neural network