Germline mutations and age at onset of lung adenocarcinoma.

Karen L ReckampCarolyn E BehrendtThomas P SlavinStacy W GrayDanielle K CastilloMarianna KoczywasMihaela C CristeaKirsten M BabskiDonna StearnsCatherine A MarcumYenni P RodriguezAmie J HassMary M VecchioPamela MoraAleck E CervantesSharon R SandRosa M MejiaTerrence C TsouRavi SalgiaJeffrey N Weitzel

Published in: Cancer (2021)

Among lung adenocarcinoma cases, germline PVs (TP53, EGFR, BRCA2, and possibly other FA genes) may be associated with an earlier onset. With further study, the criteria for lung cancer screening may need to include carriers of high-risk PVs, and findings could influence precision therapy and reduce lung cancer mortality by earlier stage diagnosis.

Keyphrases

dna repair
small cell lung cancer
cardiovascular events
tyrosine kinase
risk factors
dna damage
mesenchymal stem cells
oxidative stress
transcription factor