Subcellular location of L1 retrotransposon-encoded ORF1p, reverse transcription products, and DNA sensors in lupus granulocytes.

Fatemeh MoadabSepideh SohrabiXiaoxing WangRayan NajjarJustina C WoltersHua JiangWenyan MiaoDonna RomeroDennis M ZallerMegan TranAlison BaysMartin S TaylorRosana KapellerJohn LaCavaTomas Mustelin

Published in: Mobile DNA (2024)

These results bring new insights into the composition of ORF1p granules in SLE neutrophils and may explain, in part, why proteins in these granules become targeted by autoantibodies in this disease.

Keyphrases

systemic lupus erythematosus
disease activity
circulating tumor
cell free
single molecule
cancer therapy
transcription factor
low cost
rheumatoid arthritis
nucleic acid