Reversible pH-responsive MRI contrast with paramagnetic polymer micelles.
Connor M EllisDaohe YuanFerenc Emil MózesJack J J J MillerJason J DavisPublished in: Chemical communications (Cambridge, England) (2023)
Paramagnetically-doped polymer micelles, containing an ionizable poly(acrylic acid) (PAA) block, support high-contrast MR imaging at clinically relevant field strengths in a manner that is strongly pH responsive. A reversible switch in polymer strand charge specifically has a direct impact on local rigidity, and rotational correlation time characteristics, of the integrated Gd-chelate, driving a ∼50% amplitude switch in positive contrast.