Development of a new methylation-based fetal fraction estimation assay using multiplex ddPCR.

Marios IoannidesAchilleas AchilleosSkevi KyriakouElena KypriCharalambos LoizidesKyriakos TsangarasLouiza ConstantinouGeorge KoumbarisPhilippos C Patsalis

Published in: Molecular genetics & genomic medicine (2019)

By employing a set of well-characterized DMRs, we developed a SNP-, sex- and ploidy-independent methylation-based multiplex ddPCR assay for accurate fetal fraction estimation.

Keyphrases

high throughput
genome wide
dna methylation
real time pcr
single cell
high resolution