TEM1/endosialin/CD248 promotes pathologic scarring and TGF-β activity through its receptor stability in dermal fibroblasts.

Yi-Kai HongYu-Chen LinTsung-Lin ChengChao-Han LaiYi-Han ChangYu-Lun HuangChia-Yi HungChen-Han WuKuo-Shu HungYa-Chu KuYen-Ting HoMing-Jer TangShu-Wha LinGuey-Yueh ShiJohn A McGrathHua-Lin WuChao-Kai Hsu

Published in: Journal of biomedical science (2024)

Our data indicate that TEM1 plays a role in pathologic scarring, with its synergistic effect on the TGF-β signaling contributing to dermal fibroblast activation. Targeting TEM1 may represent a novel therapeutic approach in reducing the morbidity of pathologic scars.

Keyphrases

neoadjuvant chemotherapy
locally advanced
transforming growth factor
wound healing
electronic health record
lymph node
cancer therapy
rectal cancer
squamous cell carcinoma
big data
epithelial mesenchymal transition
radiation therapy
deep learning
platelet rich plasma