Population pharmacokinetics of micafungin over repeated doses in critically ill patients: a need for a loading dose?

Iasonas KapralosEfstratios MainasEfthymios NeroutsosStella ApostolidiMaria SiopiOlympia ApostolopoulouGeorge DimopoulosHelen SambatakouGeorgia ValsamiJoseph Meletiadis Aristides Dokoumetzidis

Published in: The Journal of pharmacy and pharmacology (2020)

A loading dose of up to 300 mg of micafungin is needed for the treatment of invasive candidiasis in ICU patients while a maintenance dose of up to 200 mg can be considered in empirical antifungal treatment.

Keyphrases

end stage renal disease
candida albicans
intensive care unit
newly diagnosed
chronic kidney disease
prognostic factors
combination therapy
mechanical ventilation