Impact of high salt diets on CHOP-mediated apoptosis and renal fibrosis in a rat model.

Tooka Khadive Darya Ghadimi Mina Hemmati Hannaneh Golshahi

Published in: Molecular biology reports (2021)

Excessive salt intake leads to fibrosis as it induces the PERK/ATF4/CHOP/BCL-2 signaling pathway in renal tissues. KIM-1 is detectable in urine before the impairment of renal function which can be used as a diagnostic marker to prevent the development of progressive renal failure.

Keyphrases

diffuse large b cell lymphoma
signaling pathway
endoplasmic reticulum stress
weight gain
multiple sclerosis
gene expression
pi k akt
induced apoptosis
transcription factor
epithelial mesenchymal transition
liver fibrosis
body mass index
cell proliferation