Placental methylome reveals a 22q13.33 brain regulatory gene locus associated with autism.

Yihui ZhuJ Antonio GomezBenjamin I LauferCharles E MordauntJulia S MouatDaniela C SotoMegan Y DennisKelly S BenkeKelly M BakulskiJohn DouRia MaratheJulia M JianuLogan A WilliamsOrangel J Gutierrez FugónCheryl K WalkerSally OzonoffJason DanielsLuke P GrosvenorHeather E VolkJason I FeinbergM Daniele FallinIrva Hertz-PicciottoRebecca J SchmidtDag H YasuiJanine M LaSalle

Published in: Genome biology (2022)

Together, these results identify and initially characterize a novel environmentally responsive ASD risk gene relevant to brain development in a hitherto under-characterized region of the human genome.

Keyphrases

autism spectrum disorder
genome wide
resting state
white matter
copy number
endothelial cells
intellectual disability
functional connectivity
genome wide identification
cerebral ischemia
dna methylation
cancer therapy
genome wide analysis