Leptomeningeal metastatic cells adopt two phenotypic states.

Ján Remšík Yudan ChiXinran TongUgur SenerCamille DerderianAbigail ParkFadi SaadehTejus BaleAdrienne A Boire

Published in: Cancer reports (Hoboken, N.J.) (2020)

Together, these data support mechanistic evidence of a metabolic adaptation that allows cancer cells to thrive in their natural environment but leads to death in vitro.

Keyphrases

induced apoptosis
cell cycle arrest
small cell lung cancer
squamous cell carcinoma
electronic health record
big data
cerebrospinal fluid
endoplasmic reticulum stress
signaling pathway
cell death
oxidative stress
brain metastases
cell proliferation
data analysis
pi k akt