Progress and gaps of extracellular vesicle-mediated intercellular cargo transfer in the central nervous system.
Chun WanMichael H B StowellJingshi ShenPublished in: Communications biology (2022)
A fundamentally novel function proposed for extracellular vesicles (EVs) is to transfer bioactive molecules in intercellular signaling. In this minireview, we discuss recent progress on EV-mediated cargo transfer in the central nervous system (CNS) and major gaps in previous studies. We also suggest a set of experiments necessary for bridging the gaps and establishing the physiological roles of EV-mediated cargo transfer.