The Impact of Li Fraumeni and Germline Retinoblastoma Mutations on Leiomyosarcoma Initiation, Outcomes and Genetic Testing Recommendations.

Josephine Kam Tai K Dermawan David H Abramson Sarah Chiang Martee L Hensley William D Tap Sujana Movva Robert G Maki Diana L Mandelker Cristina R Antonescu

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

While ULMS patients had a relatively low proportion of PGV, a high percentage of STLMS patients with PGV had tumor biallelic status, indicating that PGV drive tumorigenesis in these individuals. These findings have significant implications for genetic testing recommendations.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
clinical practice
prognostic factors
peritoneal dialysis
intellectual disability
type diabetes
metabolic syndrome
autism spectrum disorder
patient reported