Multi-ancestry phenome-wide association of complement component 4 variation with psychiatric and brain phenotypes in youth.

Leanna M HernandezMinsoo KimPan ZhangRichard A I BethlehemGil HoftmanRobert LoughnanDiana SmithSusan Y BookheimerChun Chieh FanCarrie E BeardenWesley K ThompsonMichael J Gandal

Published in: Genome biology (2023)

Our results suggest neurodevelopmental effects of C4A on childhood medial temporal lobe structure, which may serve as a biomarker for schizophrenia risk prior to symptom onset.

Keyphrases

mental health
bipolar disorder
resting state
white matter
physical activity
young adults
early life
functional connectivity
cerebral ischemia
multiple sclerosis
patient reported
brain injury