Comprehensive Molecular Evaluation of HNF-1 Alpha, miR-27a, and miR-146 Gene Variants and Their Link with Predisposition and Progression in Type 2 Diabetes Patients.
Rashid MirImadeldin ElfakiM E ElangeebMamdoh S MoawadhFaris Jamal TayebJameel BarnawiIbrahim Altedlawi AlbalawiAmnah A AlharbiMarwan H AlhelaliBasim S O AlsaediPublished in: Journal of personalized medicine (2023)
The SNVs in miR-27a, miR-146, and HNF-1 alpha can be potential loci for T2D risk. The limitations of this study include the relatively small sample size and the fact that it was a cross-sectional study. To our knowledge, this is the first study to highlight the association between miR-27a, miR-146, and HNF-1 alpha SNVs and the risk of T2D in the Saudi population. Future large-scale case-control studies, as well as studies on the functions of the proteins and protein interaction studies for HNF-1 alpha, are required to verify our findings. Furthermore, these findings can be used for the identification and stratification of at-risk populations via genetic testing for T2D-prevention strategies.
Keyphrases
- cell proliferation
- long non coding rna
- case control
- long noncoding rna
- type diabetes
- nuclear factor
- genome wide
- cardiovascular disease
- ejection fraction
- risk factors
- metabolic syndrome
- dna methylation
- gene expression
- risk assessment
- small molecule
- transcription factor
- current status
- human health
- bioinformatics analysis
- patient reported