Comprehensive Characterization of the Multiple Myeloma Immune Microenvironment Using Integrated scRNA-seq, CyTOF, and CITE-seq Analysis.
Lijun YaoReyka G JayasingheBrian H LeeSwati S BhasinWilliam PilcherDeon Bryant DoxieEdgar Gonzalez-KozlovaSurendra DasariMark A FialaYered Pita-JuarezMichael StrausbauchGeoffrey KellyBeena E ThomasShaji K KumarHearn Jay ChoEmilie AndersonMichael C WendlTravis DawsonDarwin D'souzaStephen T OhGiulia CheloniYing LiJohn F DiPersioAdeeb H RahmanKavita M DhodapkarSeunghee Kim-SchulzeRavi VijIoannis S VlachosShaadi MehrMark HamiltonDaniel AuclairTaxiarchis KourelisDavid AviganMadhav V DhodapkarSacha GnjaticManoj K BhasinLi DingPublished in: Cancer research communications (2022)
scRNA-seq, CyTOF, and CITE-seq are increasingly used for evaluating cellular heterogeneity. Understanding their concordances is of great interest. To date, this study is the most comprehensive examination of the measurement of the immune microenvironment in multiple myeloma using the three techniques. Moreover, we identified markers predicted to be significantly associated with multiple myeloma rapid progression.