Implications for sequencing of biologic therapy and choice of second anti-TNF in patients with inflammatory bowel disease: results from the IMmunogenicity to Second Anti-TNF therapy (IMSAT) therapeutic drug monitoring study.
Neil ChanchlaniSimeng LinMarcus Karl-Heinz AuthChai Leng LeeHelena RobbinsShi LooiSenthil V MurugesanTom RileyCathryn PrestonSophie StephensonWendy CardozoSunil A SonwalkarMohammed Allah-DittaLynne MansfieldDharmaraj DuraiMark BakerIan LondonEmily LondonSanjay GuptaAlex Di MambroAisling MurphyEdward GaynorKelsey D J JonesAndrew ClaridgeShaji SebastianSankaranarayanan RamachandranChristian Philipp SelingerSimon P Borg-BartoloPaul KnightMichael B SprakesJulie BurtonPatricia KaneStephanie LuptonAimee FletcherDaniel R GayaRoghan ColbertJohn Paul SeenanJonathan MacdonaldLucy LynchIain McLachlanStephanie ShieldsRichard HansenLisa GervaisMwansa JereMuhammad AkhtarKaren BlackPaul HendersonRichard Kay RussellCharlie W LeesLauranne A A P DerikxMelanie LockettFrederica BetteridgeAminda De SilvaArif HussenbuxJohn BecklyOliver BendallJames W HartAmanda ThomasBenjamin HamiltonClaire GordonDesmond CheeTimothy James McDonaldRachel NiceMarian ParkinsonHelen Gardner-ThorpeJeff R ButterworthAsima JavedSarah Al-ShakhshirRekha YadagiriSebrene MaherRichard C G PollokTze NgPriscilla AppiaheneFiona DonovanJames LokRajiv ChandyReema JagdishDaniyal BaigZahid MahmoodLiane MarshAllison MossAmin AbdulgaderAngus KitchinGareth J WalkerBecky GeorgeYuen-Hui LimJames GulliverStuart BloomHolly TheakerSean CarlsonJ R Fraser CummingsRobert LivingstoneAmanda BealeJosiah O CarterAndrew BellArchibald CoulterJonathon SnookHelen StoneNicholas Alexander KennedyJames R GoodhandTariq Ahmadnull nullPublished in: Alimentary pharmacology & therapeutics (2022)
Irrespective of drug sequence, immunogenicity to the first anti-TNF agent was associated with immunogenicity to the second, which was mitigated by the introduction of an immunomodulator in patients with immunogenic, but not pharmacodynamic treatment failure.