Pharmacogenetics may explain part of the interindividual variability of dobutamine pharmacodynamics in neonates.
Maarja HallikHiie SoeorgTiina KahreÜlle MurumetsMari-Liis IlmojaKarin KipperTuuli MetsvahtPublished in: British journal of clinical pharmacology (2022)
In critically ill neonates, β1-AR Arg389Gly and GNAS c.393C > T polymorphisms may play a role in the haemodynamic response to dobutamine during the first hours and days of life.