Toll-like receptor 4 signalling mediates inflammation in skeletal muscle of patients with chronic kidney disease.

Daniela VerzolaAlice BonanniAntonella SofiaFabrizio MontecuccoElena D'AmatoValeria CademartoriEmanuele Luigi ParodiFrancesca ViazziChiara VenturelliGiuliano BrunoriGiacomo Garibotto

Published in: Journal of cachexia, sarcopenia and muscle (2016)

CKD promotes muscle inflammation through an up-regulation of TLR4, which may activate downward inflammatory signals such as TNF-α and NFkB-regulated genes.

Keyphrases

toll like receptor
skeletal muscle
oxidative stress
nuclear factor
inflammatory response
immune response
rheumatoid arthritis
insulin resistance
chronic kidney disease
transcription factor
genome wide
type diabetes
gene expression
adipose tissue
metabolic syndrome
dna methylation