Eight new sesquiterpenes, namely, albocinnamins A-H ( 1 - 8 ), along with two known ones ( 9 and 10 ), have been isolated from the fungus Antrodiella albocinnamomea . Compound 1 possesses a new backbone that might be derived from cadinane-type sesquiterpene. Structures of the new compounds were elucidated by detailed spectroscopic data analysis, single-crystal X-ray diffraction, and ECD calculations. Compounds 1a and 1b showed cytotoxicity against SW480 and MCF-7 cells, with IC 50 values ranging from 19.3 to 33.3 μM, while compound 2 displayed cytotoxicity against the HL-60 cell with an IC 50 value of 12.3 μM. In addition, compounds 5 and 6 exhibited antibacterial activity against Staphylococcus aureus with MIC values of 64 and 64 µg/mL, respectively.
Keyphrases
- data analysis
- staphylococcus aureus
- high resolution
- induced apoptosis
- cell cycle arrest
- single cell
- silver nanoparticles
- molecular dynamics
- molecular docking
- molecular dynamics simulations
- cell therapy
- density functional theory
- magnetic resonance imaging
- oxidative stress
- cell death
- electron microscopy
- biofilm formation
- mesenchymal stem cells
- bone marrow
- cell proliferation
- pi k akt
- cystic fibrosis
- solid state