Effect of Rho-Kinase and Autophagy on Remote Ischemic Conditioning-Induced Cardioprotection in Rat Myocardial Ischemia/Reperfusion Injury Model.

Jie GaoFeng MinShasha Wang Heng LvHuan LiangBen CaiXianjie Jia Qin Gao Ying Yu

Published in: Cardiovascular therapeutics (2022)

These results showed that RIC protected the myocardium from I/R injury by suppressing Rho-kinase and the underlying mechanism may be related to enhancing autophagy via the PI3K/AKT pathway.

Keyphrases

protein kinase
ischemia reperfusion injury
oxidative stress
diabetic rats
cell death
endoplasmic reticulum stress
signaling pathway
high glucose
tyrosine kinase
smooth muscle
drug induced
heart failure
endothelial cells
brain injury