Current status and future prospects of transforming growth factor-β as a potential prognostic and therapeutic target in the treatment of breast cancer.
Forouzan AmerizadehAfsane BahramiMajid KhazaeiAmirReza HesariMajid RezayiSahar TalebianMona MaftouhMehrdad Moetamani-AhmadiSima SeifiSoodabeh ShahidsalesMona Joudi-MashhadGordon A FernsFaezeh GhasemiSoodabeh ShahidsalesPublished in: Journal of cellular biochemistry (2019)
The transforming growth factor-β (TGF-β) signaling pathway is one of the important pathways involved in the cancer cell proliferation, invasion, migration, angiogenesis, apoptosis, as well as in metastasis by agitation or invasion of metastasis-related factors, including matrix metalloproteinase (MMP), epithelial-to-mesenchymal transition (EMT), tumor microenvironment (TME), cancer stem cells (CSCs), and cell adhesion molecules (CAMs). These data suggest its potential value as a therapeutic object in the treatment of malignancies including breast cancer. Several pharmacological approaches have been established to suppress TGF-β pathway; such as vaccines, small molecular inhibitors, antisense oligonucleotides, and monoclonal antibodies. Some of these are now approved by the US Food and Drug Administration for targeting the TGF-β signaling pathway. This study attempts to summarize the current data about the functions of TGF-β in cancer cells, and their probable application in the cancer therapy with a specific emphasis on recent preclinical and clinical research in the treatment of breast cancer and its prognostic value.
Keyphrases
- transforming growth factor
- epithelial mesenchymal transition
- signaling pathway
- cancer therapy
- cell proliferation
- cancer stem cells
- drug administration
- oxidative stress
- cell adhesion
- machine learning
- risk assessment
- big data
- climate change
- lymph node metastasis
- papillary thyroid
- single molecule
- endoplasmic reticulum stress
- induced apoptosis
- squamous cell