Latent class cluster analysis identified hidden headache phenotypes in COVID-19: impact of pulmonary infiltration and IL-6.

Karadaş Ömer Bilgin Öztürk Ali Rıza Sonkaya Bahar Taşdelen Aynur Ozge Hayrunnisa Bolay Belen

Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2021)

The intensity, duration, frequency, bilateral frontal location, and treatment response of COVID-19 headache was related to pulmonary involvement and IL-6 levels, which indicated a role of inflammation in determining the headache manifestations in moderately affected hospitalized patients. ROC curve cutoff values pointed that VAS > 70 severity, > 9 h duration, > 5 headache days, and IL-6 > 43 pg/mL levels can be diagnostic for COVID-19 headache. GON blocks can effectively abort headache when patients are unresponsive to paracetamol, and other NSAIDs are avoided during the SARS-CoV-2 infection.

Keyphrases

coronavirus disease
sars cov
pulmonary hypertension
end stage renal disease
oxidative stress
ejection fraction
newly diagnosed
working memory
peritoneal dialysis
high intensity
patient reported outcomes