A Phase 1 Study to Evaluate the Drug Interaction Between Islatravir (MK-8591) and Doravirine in Adults Without HIV.

Randolph P MatthewsDeanne Jackson RuddKerry L FillgroveSaijuan ZhangCharles TomekS Aubrey StochMarian Iwamoto

Published in: Clinical drug investigation (2021)

These results indicate that coadministration of islatravir and doravirine had no clinically meaningful effect on the pharmacokinetics of either drug, and support further clinical investigation of islatravir in combination with doravirine for the treatment of HIV-1 infection.

Keyphrases

antiretroviral therapy
hiv infected
human immunodeficiency virus
hiv positive
hiv aids
hepatitis c virus
hiv testing
open label
drug induced
emergency department
clinical trial
men who have sex with men
south africa