Early diagnosis of pathogenic bacteria and treatment are essential to prevent further infection. Photothermal therapy (PTT) is a promising sterilization method with advantages of minimal invasiveness and high efficiency. The effect of PTT depends on the performance of photothermal materials. Herein, Ti 3 C 2 -Au nanomaterials were prepared by the electrostatic self-assembly method, and the absorption characteristics were modulated by changing the morphology of Ti 3 C 2 -Au to achieve high photothermal conversion efficiency and sensitive label-free SERS bacterial detection. The results showed that the prepared Ti 3 C 2 -Au had better SERS performance than Au and achieved direct and sensitive detection of Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ). Under 808 nm laser irradiation, the photothermal conversion efficiency of Ti 3 C 2 -Au nanobipyramids (NBPs) was increased to 50.41% compared with the other two composites. The bactericidal rates of Ti 3 C 2 -Au NBPs against E. coli and S. aureus were 95.11 and 99.80% in 8 min, respectively, and the killing rates of nine other bacteria were all above 95%, showing broad-spectrum antibacterial properties. Cell viability studies showed that the Ti 3 C 2 -Au NBP had significantly improved biocompatibility compared with the Au NBP and was suitable for biological applications. It can simultaneously realize sensitive bacterial detection and photothermal sterilization and is important for the detection and inhibition of pathogenic bacteria.
Keyphrases
- sensitive detection
- label free
- loop mediated isothermal amplification
- quantum dots
- photodynamic therapy
- escherichia coli
- cancer therapy
- reduced graphene oxide
- drug delivery
- staphylococcus aureus
- high efficiency
- gold nanoparticles
- real time pcr
- radiation therapy
- high resolution
- multidrug resistant
- anti inflammatory
- raman spectroscopy