Positive predictive value of a single nucleotide polymorphism (SNP)-based NIPT for aneuploidy in twins: Experience from clinical practice.

Valerie KantorLihong MoWendy DiNonnoKatherine HowardCharuta C PalsuledesaiSheetal ParmarZahabiya ChithiwalaRuss JelsemaWenbo XuHerman L Hedriana

Published in: Prenatal diagnosis (2022)

The performance of SNP-based NIPT in this large twin cohort was comparable to previously reported twin NIPT studies. SNP-based NIPT allows for zygosity-based PPV assessment.

Keyphrases

genome wide
clinical practice
high density
dna methylation
genetic diversity
case control
clinical evaluation