Login / Signup

Targeting the TGF-β signaling pathway for fibrosis therapy: a patent review (2015-2020).

Xuanyi LiZiang DingZixuan WuYinqiu XuHequan YaoKejiang Lin
Published in: Expert opinion on therapeutic patents (2021)
Since the approval of pirfenidone, targeting TGF-β signaling has been anticipated as an effective therapy for fibrosis. The potential of this therapy has been further supported by emerging patents on the TGF-β signaling. This pathway can be entirely inhibited, from the activation of TGF-β to downstream signaling. Inhibiting TGF-β signaling is expected to provide more effective treatments for fibrosis.
Keyphrases
  • transforming growth factor
  • signaling pathway
  • epithelial mesenchymal transition
  • cancer therapy
  • stem cells
  • idiopathic pulmonary fibrosis
  • mesenchymal stem cells
  • endoplasmic reticulum stress
  • climate change