BODIPY-Labeled Cyclobutanes by Secondary C(sp3 )-H Arylations for Live-Cell Imaging.

Matteo VirelliWei WangRositha KuniyilJun WuGiuseppe ZanoniAntonio FernandezJamie ScottMarc Vendrell Harry L Anderson

Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2019)

Arylated cyclobutanes were accessed by a versatile palladium-catalyzed secondary C(sp3 )-H activation, exploiting chelation assistance by modular triazoles. The C-H arylation led to cyclobutane natural product derivatives in a highly regioselective fashion, setting the stage for the easy access to novel fluorogenic boron-dipyrrin (BODIPY)-labeled probes for live-cell imaging.

Keyphrases

living cells
high resolution
fluorescent probe
pet imaging
fluorescence imaging
small molecule
mass spectrometry
structure activity relationship