Uncontrolled asthmatics have increased FceRI+ and TGF-β-positive MCTC mast cells and collagen VI in the alveolar parenchyma.
Cecilia K AnderssonM WeitoftK Rydell-TörmänenL BjermerG Westergren-ThorssonJonas S ErjefältPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2018)
Patients with uncontrolled atopic asthma have an altered pro-fibrotic MCTC phenotype in the alveolar parenchyma that is associated with alveolar collagen VI. The present data thus support distal lung mast cell and matrix changes as histopathological features of asthma that may be of particular clinical relevance in patients who have remaining symptoms despite conventional inhaler therapy.
Keyphrases
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