Cerebral Amyloid Angiopathy, Alzheimer's Disease and MicroRNA: miRNA as Diagnostic Biomarkers and Potential Therapeutic Targets.
J Weldon FurrDiego Morales-ScheihingBharti ManwaniJuneyoung LeeLouise D McCulloughPublished in: Neuromolecular medicine (2019)
The protein molecules must fold into unique conformations to acquire functional activity. Misfolding, aggregation, and deposition of proteins in diverse organs, the so-called "protein misfolding disorders (PMDs)", represent the conformational diseases with highly ordered assemblies, including oligomers and fibrils that are linked to neurodegeneration in brain illnesses such as cerebral amyloid angiopathy (CAA) and Alzheimer's disease (AD). Recent studies have revealed several aspects of brain pathology in CAA and AD, but both the classification and underlying mechanisms need to be further refined. MicroRNAs (miRNAs) are critical regulators of gene expression at the post-transcriptional level. Increasing evidence with the advent of RNA sequencing technology suggests possible links between miRNAs and these neurodegenerative disorders. To provide insights on the small RNA-mediated regulatory circuitry and the translational significance of miRNAs in PMDs, this review will discuss the characteristics and mechanisms of the diseases and summarize circulating or tissue-resident miRNAs associated with AD and CAA.
Keyphrases
- gene expression
- transcription factor
- cerebral ischemia
- single cell
- subarachnoid hemorrhage
- resting state
- white matter
- cognitive decline
- protein protein
- machine learning
- functional connectivity
- dna methylation
- patient safety
- binding protein
- molecular dynamics simulations
- amino acid
- small molecule
- mild cognitive impairment
- heat shock protein