First-site-metastasis pattern in patients with inoperable stage III NSCLC treated with concurrent chemoradiotherapy with or without immune check-point inhibition: a retrospective analysis.

Kerstin HofstetterJulian TaugnerLukas KäsmannSina MansoorianBenedikt FlörschChukwuka EzeAmanda TufmanNiels ReinmuthThomas DuellClaus BelkaFarkhad Manapov

Published in: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] (2023)

This retrospective analysis of inoperable stage III NSCLC patients revealed that age over 65, V20 ≥ 30 and GTV ≥ 78 cc were prognosticators for BMFS and GTV ≥ 78 cc for ecDMFS. ICI treatment led to a significant improvement of BMFS, ecDMFS and DMFS. ecDM as FSMP was associated with significant deterioration of OS, whereas BM as FSMP was not.

Keyphrases

locally advanced
small cell lung cancer
end stage renal disease
newly diagnosed
rectal cancer
ejection fraction
chronic kidney disease
advanced non small cell lung cancer
single cell
radiation therapy
brain metastases
tyrosine kinase