Pancreatic Tumor Microenvironment Modulation by EphB4-ephrinB2 Inhibition and Radiation Combination.
Shelby LennonAyman OweidaDallin MilnerAndy V PhanShilpa BhatiaBenjamin Van CourtLaurel DarraghAdam C MuellerDavid RabenJorge L Martínez-TorrecuadradaTodd M PittsHilary SomersetKimberley R JordanKirk C HansenJason WilliamsWells A MessersmithRichard D SchulickPhilip OwensKaryn A GoodmanSana D KaramPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
These are the first findings to suggest that in PDAC, ephrinB2-EphB4 interaction has a profibrotic, protumorigenic role, presenting a novel and promising therapeutic target.
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