Prediction of subtle left ventricular systolic dysfunction in homozygous and heterozygous familial hypercholesterolemia: Genetic analyses and speckle tracking echocardiography study.
Erhan SaraçoğluSalih KılıçErtan VuruşkanIrfan DüzenYusuf ÇekiciZülfiye KuzuArafat YıldırımMehmet KüçükosmanoğluMustafa ÇetinPublished in: Echocardiography (Mount Kisco, N.Y.) (2018)
This study demonstrates the potential of using systolic strain values obtained using 2D STE for determining lipotoxicity in the myocardium owing to hypercholesterolemia. Our study found that cardiac functions of homozygote patients who had the highest cholesterol levels were disrupted at very early ages. Therefore, starting lipid reduction treatment and early reverse LV remodelling therapy at early ages may be beneficial for high-risk patients.
Keyphrases
- left ventricular
- heart failure
- acute myocardial infarction
- type diabetes
- ejection fraction
- gene expression
- stem cells
- newly diagnosed
- hypertrophic cardiomyopathy
- mitral valve
- atrial fibrillation
- prognostic factors
- aortic stenosis
- percutaneous coronary intervention
- cardiac resynchronization therapy
- cardiovascular events
- combination therapy