CD4+ Memory Stem T Cells Recognizing Citrullinated Epitopes Are Expanded in Patients With Rheumatoid Arthritis and Sensitive to Tumor Necrosis Factor Blockade.
Beatrice Claudia CianciottiEliana RuggieroCorrado CampochiaroGiacomo OliveiraZulma I MagnaniMattia BaldiniMatteo DoglioMichela TassaraAngelo A ManfrediElena BaldisseraFabio CiceriNicoletta CieriChiara BoniniPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2020)
Our results indicate that Tscm cells, including expanded clones specific for relevant autoantigens, accumulate in RA patients not exposed to biologic agents, and might be involved in the natural history of the disease. Further analysis of Tscm cell dynamics in autoimmune disorders may have implications for the design and efficacy assessment of innovative therapies.
Keyphrases
- rheumatoid arthritis
- end stage renal disease
- induced apoptosis
- chronic kidney disease
- newly diagnosed
- ejection fraction
- multiple sclerosis
- single cell
- prognostic factors
- stem cells
- cell therapy
- disease activity
- cell cycle arrest
- working memory
- systemic lupus erythematosus
- mesenchymal stem cells
- ankylosing spondylitis
- oxidative stress
- bone marrow
- pi k akt
- nk cells