Hsp70, in Combination with IL-15 and PD-1 Blocker, Interferes with The Induction of Cytotoxic NK Cells in Relapsed Acute Myeloid Leukemia Patients.
Javad FirouziAbbas HajifathaliMasoumeh AzimiNeda ParviniFatemeh GhaemiNiloufar Shayan AslAmir Abbas Hedayati AslMajid SafaMarzieh EbrahimiPublished in: Cell journal (2023)
We suggested the combination of IL-15 and PD-1 blocker could enhance the killing potential of AMLNK cells. Moreover, Hsp70 in combination with IL-15 and PD-1 blocker interferes activation of AML-NK cells through unknown mechanisms.
Keyphrases
- nk cells
- acute myeloid leukemia
- end stage renal disease
- heat shock protein
- angiotensin converting enzyme
- induced apoptosis
- allogeneic hematopoietic stem cell transplantation
- newly diagnosed
- ejection fraction
- heat stress
- acute lymphoblastic leukemia
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- risk assessment
- signaling pathway
- climate change
- cell death
- hodgkin lymphoma
- endoplasmic reticulum stress