Electroacupuncture regulates Rab5a-mediating NGF transduction to improve learning and memory ability in the early stage of AD mice.

Jianhong LiMinguang YangYaling DaiXiaoqin GuoYanyi DingXiaoling LiShenghang ZhangWenshan XuLidian ChenJing Tao Weilin Liu

Published in: CNS neuroscience & therapeutics (2024)

Rab5a hyperactivation is an early pathological manifestation of 5 × FAD mice. EA could suppress Rab5a-GTP to promote the transduction of NGF signaling, and enhance the synaptic plasticity of the basal forebrain hippocampal circuit improving cognitive impairment in the early stage of 5 × FAD mice.

Keyphrases

early stage
high fat diet induced
growth factor
sentinel lymph node
type diabetes
cerebral ischemia
wild type
neuropathic pain
subarachnoid hemorrhage
locally advanced