Detection of α-Synuclein in Oral Mucosa by Seed Amplification Assay in Synucleinopathies and Isolated REM Sleep Behavior Disorder.

Yuanchu ZhengZhenwei YuHuihui CaiWenyi KouChen YangSiming LiNing ZhangTao Feng

Published in: Movement disorders : official journal of the Movement Disorder Society (2024)

Oral mucosa α-Syn seeding activity may serve as novel non-invasive diagnostic and prodromal biomarkers for synucleinopathies. The α-Syn aggregates amplified from the oral mucosa of PD and MSA exhibited distinct biochemical and biophysical properties. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyphrases

high throughput
parkinson disease
systematic review
sleep quality
loop mediated isothermal amplification
deep brain stimulation