Neurodegenerative disease biomarkers Aβ1-40, Aβ1-42, tau, and p-tau181 in the vervet monkey cerebrospinal fluid: Relation to normal aging, genetic influences, and cerebral amyloid angiopathy.

Jason A ChenScott C FearsAnna J JasinskaAlden HuangNoor B Al-SharifKevin E ScheibelThomas D DyerAnne M FaganJohn BlangeroRoger WoodsMatthew J JorgensenJay R KaplanNelson B FreimerGiovanni Coppola

Published in: Brain and behavior (2018)

Overall, these results support the vervet as a non-human primate model of amyloid-related neurodegeneration, such as Alzheimer's disease and cerebral amyloid angiopathy, and highlight Aβ1-40 and p-tau181 as potentially valuable biomarkers of these processes.

Keyphrases

cerebrospinal fluid
subarachnoid hemorrhage
endothelial cells
genome wide
cerebral ischemia
copy number
induced pluripotent stem cells
gene expression