Macrophage-derived IL-6 trans-signaling as a novel target in the pathogenesis of bronchopulmonary dysplasia.

Dharmesh HiraniCristina M AlviraSoula DanopoulosCarlos MillaMichele DonatoLu TianJasmine MohrKatharina DingerChristina VohlenJaco SelleSilke V Koningsbruggen-RietschelVerena BarbarinoChristian PallaschStefan Rose-JohnMargarete OdenthalGloria S PryhuberSiavash MansouriSoni Savai Pullamsetti Horst-Walter BirkPurvesh KhatriDenise Al AlamJörg DötschMiguel A Alejandre Alcazar

Published in: The European respiratory journal (2021)

We present a novel IL-6-mediated mechanism by which hyperoxia activates macrophages in immature lungs, impairs ATII homeostasis, and disrupts elastic fiber formation, thereby inhibiting lung growth. The data provide evidence that IL-6 trans-signaling could offer an innovative pharmacological target to enable lung growth in severe neonatal chronic lung disease.

Keyphrases

adipose tissue
signaling pathway
big data
machine learning
drug induced