Direct Tests of Cytochrome Function in the Electron Transport Chain of Malaria Parasites.

Tanya J Espino-Sanchez Henry WienkersRebecca G MarvinShai-Anne Nalder Aldo E García-Guerrero Peter E VanNatta Yasaman Jami-AlahmadiAmanda Mixon BlackwellFrank G WhitbyJames A WohlschlegelMatthew T Kieber-EmmonsChristopher P HillPaul A Sigala

Published in: bioRxiv : the preprint server for biology (2023)

is essential for ETC function and parasite viability while the second, more divergent protein has unusual structural and biochemical properties and is not required for growth of blood-stage parasites. This work elucidates key biochemical properties and evolutionary differences in the mitochondrial ETC of malaria parasites.

Keyphrases

plasmodium falciparum
oxidative stress
binding protein
protein protein
dna methylation