Olfactory swab sampling optimization for α-synuclein aggregate detection in patients with Parkinson's disease.
Matilde BongianniMauro CatalanDaniela PerraElena FontanaFrancesco JanesClaudio BertolottiLuca SacchettoStefano CapaldiMatteo TagliapietraPaola PolverinoValentina TommasiniGiulia BellavitaElham Ataie KachoieRoberto BarucaAndrea BernardiniMariarosaria ValenteMichele FioriniErika BronzatoStefano TamburinLaura BertolasiLorenzo BrozzettiMaria Paola CecchiniGianluigi GigliSalvatore MonacoPaolo ManganottiGianluigi ZanussoPublished in: Translational neurodegeneration (2022)
In PD patients, RT-QuIC sensitivity is significantly increased (from 45% to 84%) when NS is performed at AN, indicating that α-syn aggregates are preferentially detected in olfactory areas with higher concentration of olfactory neurons. Although RT-QuIC analysis of CSF showed a higher diagnostic accuracy compared to NS, due to the non-invasiveness, NS might be considered as an ancillary procedure for PD diagnosis.