SIRT1 is an actionable target to restore p53 function in HPV-associated cancer therapy.

Irene Lo CignoFederica CalatiCarlo GironeCinzia BorgognaAldo VenutiRenzo L Boldorini Marisa Gariglio

Published in: British journal of cancer (2023)

Our findings uncover an essential role of SIRT1 in HPV-driven oncogenesis, which may have direct translational implications for the treatment of this type of cancer.

Keyphrases

cancer therapy
high grade
oxidative stress
papillary thyroid
ischemia reperfusion injury
drug delivery
cervical cancer screening
squamous cell carcinoma
combination therapy