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SIRT1 is an actionable target to restore p53 function in HPV-associated cancer therapy.

Irene Lo CignoFederica CalatiCarlo GironeCinzia BorgognaAldo VenutiRenzo L BoldoriniMarisa Gariglio
Published in: British journal of cancer (2023)
Our findings uncover an essential role of SIRT1 in HPV-driven oncogenesis, which may have direct translational implications for the treatment of this type of cancer.
Keyphrases
  • cancer therapy
  • high grade
  • oxidative stress
  • papillary thyroid
  • ischemia reperfusion injury
  • drug delivery
  • cervical cancer screening
  • squamous cell carcinoma
  • combination therapy