Mass spectrometric characterization of intact desferal-conjugated monoclonal antibodies for immuno-PET imaging.
Thomas De VijlderJens FissersBianca Van BroeckLeonie WyffelsMarc MerckenDarrel J PembertonPublished in: Rapid communications in mass spectrometry : RCM (2018)
An efficient intact mass analysis-based process was developed to reproducibly determine the integrity of monoclonal antibodies and the quantity of attached chelator. This technique could serve as an essential quality control approach for the development and production of immuno-PET tracers.