Impaired calcium influx underlies skewed T helper cell differentiation in children with IgE-mediated food allergies.
C L LaiB Santner-NananP J MalteseC K S OngDebra J PalmerD E CampbellM MakridesM GoldR NananSusan L PrescottPeter S HsuPublished in: Allergy (2024)
In children with IgE-mediated food allergies, dysregulation of T helper cell development is associated with impaired SOCE, which underlies an intrinsic impairment in Th1 and Treg differentiation. Along with tacrolimus-induced Th2 skewing, this highlights an important role of SOCE/calcineurin pathway in T helper cell differentiation.