Association between sickle cell anemia and alpha thalassemia reveals a high prevalence of the α3.7 triplication in congolese patients than in worldwide series.
Tite Minga MikobiProsper Tshilobo LukusaMichel Ntetani AloniAimé LumakaPierre Zalagile AkilimaliKoenraad DevriendtGert MatthijsJean-Marie Mbuyi MuambaValerie RacePublished in: Journal of clinical laboratory analysis (2017)
The prevalence of α3.7 triplication was higher in sickle cell patients in the Democratic Republic of Congo than in worldwide series. The α3.7 triplication and α3.7 homozygous deletion were associated with less severe forms of the Sickle cell anemia in Congolese patients. These results showed the need to investigate systematically the alpha-globin gene mutations in sickle cell population in Central Africa.