Longitudinal gut microbiome analyses and blooms of pathogenic strains during lupus disease flares.
Doua AzzouzZe ChenPeter M IzmirlyLea Ann ChenZhi LiChongda ZhangDavid MielesKate TrujilloAdriana HeguyAlejandro PirontiGreg G PutzelDominik SchwudkeDavid FenyoJill P BuyonAlexander V AlekseyenkoNicolas GischGregg J SilvermanPublished in: Annals of the rheumatic diseases (2023)
Our findings rationalise how blooms of the RG pathobiont may be common drivers of clinical flares of often remitting-relapsing lupus disease, and highlight the potential pathogenic properties of specific strains isolated from active LN patients.