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PLGA microparticle formulations for tunable delivery of a nano-engineered filamentous bacteriophage-based vaccine: in vitro and in silico-supported approach.

Rezvan JamaledinRossella SartoriusConcetta Di NataleValentina OnestoRoberta MancoValentina MolloRaffaele VecchionePiergiuseppe De BerardinisPaolo Antonio Netti
Published in: Journal of nanostructure in chemistry (2023)
Synopsis: administration of recombinant bacteriophage-loaded PLGA microparticles for antigen delivery. PLGA microparticles release the bacteriophages, inducing activation of dendritic cells and enhancing antigen presentation and specific T cell response. Bacteriophage-encapsulated microneedles potentially can be administered into human body and generate robust immune responses.
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