Ceria Nanozymes with Preferential Renal Uptake for Acute Kidney Injury Alleviation.
Dong-Yang ZhangHengke LiuChunying LiMuhammad Rizwan YounisShan LeiChen YangJing LinZhiming LiPeng HuangPublished in: ACS applied materials & interfaces (2020)
Rhabdomyolysis-induced acute kidney injury (AKI) is closely related to abundant reactive oxygen species (ROS). Owing to the multi-enzymatic activity and broad-spectrum ROS scavenging capacity of ceria nanoparticles (ceria NPs), herein, we report ultrasmall citric acid modified ceria nanozymes (3-4 nm) as antioxidants to alleviate rhabdomyolysis-induced AKI through removing excessive ROS. The as-prepared ceria NPs exhibited multi-enzymatic properties such as peroxidase, catalase, and superoxide dismutase, offering efficient protection of renal cells against H2O2 stimulation in vitro. Moreover, due to their ultrasmall size, ceria NPs could efficiently accumulate in the kidneys, thus protecting renal cells against ROS in vivo. Our results present ultrasmall ceria nanozymes as antioxidants for rhabdomyolysis-induced AKI alleviation, which shows great potential in clinic.
Keyphrases
- acute kidney injury
- reactive oxygen species
- cardiac surgery
- cell death
- induced apoptosis
- cell cycle arrest
- high glucose
- dna damage
- hydrogen peroxide
- diabetic rats
- drug induced
- primary care
- endoplasmic reticulum stress
- signaling pathway
- body mass index
- risk assessment
- physical activity
- climate change
- oxide nanoparticles
- pi k akt